KMID : 0359919860050010082
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Korean Journal of Nephrology 1986 Volume.5 No. 1 p.82 ~ p.88
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An Experience of Hemoperfusion in Paraquat Poisoning
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Kim Si-Hwan
Choi Soo-Bong
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Abstract
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Paraquat is a widely used herbicide and its ingestion induces acute renal failure, hepatic dysfunction and progressive respiratory failure with high mortality rate.
Charcoal hemoperfusion has been used in the treatment of various poisoning including paraquat since 1948, but it has not been reported yet in Korea. So we report charcoal hemoperfusion in a case of paraquat poisoning with review of literature.
The present case was a 14-year-old female who was admitted due to dysphagia and epigastric pain. The above mentioned chief complaints occurred 6 days prior to admission when she ingested paraquat with suicidal attempt.
She was treated with 4 times of charcoal hemoperfusion using Gambro Adsorba 150C in addition to conventional treatment and achieved favorable progress in both clinical and laboratory examination.
Up to 7 months after paraquat poisoning she was free of any _Complication so we presume that she was completely recovered from the deleterious effect of paraquat.
Hemoperfusion is a safe, effective and simple method of treating severe poisoning and it seems to be of particular value in paraquat poisoning because it is endemic in Korea and no specific treatment is available in paraquat poisoning.
We suggest that measurement of various serum drug level should be available and further evaluation of hemoperfusion in various disease states are necessary.
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